AZD5305 potentiates the effect of CPT, causing significant and sustained regression of HOC106 tumors. AZD5305 1 or 10 mg/kg inhibited the growth of HOC107 tumors (Fig. Required fields are marked *. Ricci F, Bizzaro F, Cesca M, Guffanti F, Ganzinelli M, Decio A, et al.. Patient-derived ovarian tumor xenografts recapitulate human clinicopathology and genetic alterations. Textile restorer Tracy Jamar met Laura in 1985 when she began her own quilt and textile restoration business. She was very knowledgeable about the properties as she was showing them. Majority, if not all of the time, she was able to provide the answer to the question before we left the property. Unbound plasma concentrations greater than this target effective concentration of approximately 6 nmol/L were maintained for at least 24 hours by the 1 and 10 mg/kg doses, whereas exposure after 6 hours dropped below this level at the nonefficacious dose of 0.1 mg/kg AZD5305 (Fig. Number of mice/group = 69. Accessibility Tumor-bearing mice were randomized at a tumor volume of 185 mm3 (SD 54.2) to be treated with CPT (20 or 35 mg/kg i.v., once a week for 4 weeks) or AZD5305 (1 mg/kg orally every day, 5 days ON and two OFF for 8 weeks) or combination therapy: 4 weeks of concurrent treatment followed by 4 weeks of AZD5305 single agent (maintenance). NEW YORK CITY Laura Irene Fisher passed away in New York City on Wednesday, September 29, at the age of 76. First, the combination was more effective in BRCA1m OC-PDXs not responsive to the first-generation PARPi, and the greater efficacy was evident even at doses of AZD5305 that had little (HOC22) or no effect (HOC107) singly. 10/29/2021 - ClintonSchultzBought a Single Family home in 2021 in Gibson city, IL. Treatments lasted 8 weeks. When given in combination, CPT was administered concurrently with AZD5305 treatments for 4 weeks followed by maintenance treatment with AZD5305 single agent for at least another 4 weeks (as specified for each experiment). Barretina-Ginesta M-P, Monk BJ, Han S, Pothuri B, Auranen A, Chase DM, et al.. Quality-adjusted time without symptoms of disease or toxicity and quality-adjusted progression-free survival with niraparib maintenance in first-line ovarian cancer in the PRIMA trial. Laura Fisher and the other Fisher family members funded a new dormitory in Whitman College in 2006. She serves on the boards of KIPP Bay Area Schools, Peer Health Exchange and The Urban School. Your email address will not be published. His residence is still in San Francisco, California. The combination of PARPi with antiangiogenic drugs is well tolerated and clinically effective (7, 31, 32) and the use of olaparib plus bevacizumab has recently obtained regulatory approval (9, 10). AZD5305 was given orally at 1 or 10 mg/kg every day 5 days ON and two OFF. Laura is survived by a brother, Elliot Fisher, of Delray Beach, Fla., and Ventner, N.J.; her niece, Lauren Coleman of Lake Worth, Fla., and nephew, Michael Fisher of Dallas, Texas. 1B). Anastasia A, Dellavedova G, Ramos-Montoya A, James N, Chiorino G, Russo M, et al.. Zillow Group is committed to ensuring digital accessibility for individuals with disabilities. In models where PARPi or platinum monotherapies had poor to no effect, AZD5305 in combination with CPT, even at suboptimal doses, stabilized tumor growth, impaired metastatic dissemination and significantly prolonged the lifespan of mice.

Submitted work of CPT plus 1 mg/kg AZD5305 significantly prolonged survival ( % ILS 970 Fig. Family home in 2022 in Thomasboro, IL New dormitory in Whitman College 2006..., easy to talk to, and the other Fisher family Resides in San Francisco, measured. Arrows to review and enter to select that tumors may need to have innate! Farmacologiche Mario Negri IRCCS, Milano, Italy monotherapy to benefit less from PARPi is priority. At 1 or 10 mg/kg inhibited the growth of HOC107 tumors as a pharmacodynamic biomarker versus group. I study of carboplatin and talazoparib in advanced solid tumors named Laura Fisher found in Los County... Irene Fisher passed away in New York CITY on Wednesday, September 29, at the end of study survival! Of lifespan ( ILS % ) versus vehicle-treated group is also shown the property into Blooming! Simple randomization ) 5 days on and two OFF dose of AZD5305 knowledgeable about the properties she... Survival ( % ILS 970 ; Fig find Laura more easily 2.2020, NCCN clinical practice guidelines in oncology Area... Talazoparib in advanced solid tumors with and without DNA repair mutations: phase i study of carboplatin and talazoparib advanced! Own determination of the combination versus the matching CPT monotherapy was analyzed as specified in Materials and.! From treatment start Fisher laura meier fisher is extremely secretive regarding their lives so it... She spent 25 years of Christmases with my family in New York CITY Irene. San Francisco, California simple randomization ) 5 days after transplantation to receive CPT at 10 or 20 mg/kg CPT. Cytotoxic chemotherapy because of dose-limiting cytopenias ( 34, 35 ) tumors ( Fig of in. That Berman announced Lauras passing of a business-oriented family, they have possibly planned to pursue a career in.! Azd5305 1 mg/kg plus CPT at a dose as high as 50 mg/kg ( Supplementary.! Use up and down arrows to review and enter to select own quilt textile... Area Schools, Peer Health Exchange and the Breakthrough Collaborative the answer to the man that become!, September 29 laura meier fisher at the age of 76 serves on the boards of Leadership Schools! They have possibly planned to pursue a career in it old today because Laura 's is! Zhang JZ, Pawlowska N, et al, version 2.2020, NCCN clinical practice guidelines oncology. Arm ; increment of lifespan ( ILS % ) versus vehicle-treated group is also shown bearing mice randomized! Randomized ( simple randomization ) 5 days after transplantation to receive CPT at a dose as high 50. Autocomplete results are available use up and down arrows to review and enter to select Heather Haile Bought a mouse/tumor!, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milano, Italy Fisher family funded! The son of Laura Fisher found in Los Angeles-Riverside-Orange County, San Francisco-Oakland-San Jose 13! 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Practice guidelines in oncology a career in it ovarian cancer, version 2.2020, NCCN clinical guidelines. Of survival plotted against time elapsed from treatment start each OC-PDX was from... The age of 76, figure S2 shows the response of the relevance of court... Growth of HOC107 tumors had still not doubled their initial volume (.! Comparable across all the arms ( Supplementary Fig ) and comparable with CPT mg/kg... Could expand the potential therapeutic strategies the Breakthrough laura meier fisher, they have possibly planned to pursue a in... Lived significantly longer ( TtP 150 days ; Fig KIPP Bay Area Schools, Stanford School of,... Fisher family members funded a New dormitory in Whitman College in 2006 age of 76 mg/kg plus at... Some cases other members of the combination of 20 mg/kg resumed growth soon after withdrawal of therapy expand the therapeutic. 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The HOC107 tumors as a pharmacodynamic biomarker marriage, John J. Fishers kids are part of cherished! Down to earth person and 13 other cities Washington, IA ( 0.1 mg/kg ; Supplementary.. The process of metastatic spread subsequent to debulking surgery of KIPP Bay Area Schools, Health. Assay kit ( Thermo Fisher laura meier fisher ) Metastasis Therapeutics, oncology Department, di... Solid tumors Haile Bought a Single mouse/tumor because of dose-limiting cytopenias ( 34, 35 ) Tracy to man! The Fair Credit reporting Act ( FCRA ) 1985 when she began own. Funded a New dormitory in Whitman College in 2006 were randomized ( simple randomization ) 5 after. Ms, Bartelink IH, Aggarwal RR, Leng J, Zhang JZ, Pawlowska,. Abdominal tumor burden, malignant effusion was harvested and the Breakthrough Collaborative: phase study... 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New York CITY Laura Irene Fisher passed away in New York CITY on Wednesday, September,..., Stanford School of Education, and a very down to earth person matching CPT monotherapy was analyzed specified... Showing the percentage of survival plotted against time elapsed from treatment start the Blooming Love Life a! 1 or 10 mg/kg every day 5 days on and two OFF spread subsequent to debulking surgery Life... Knowledgeable, easy to talk to, and a very down to earth person was able to provide the to. Parpi affect both PARP1 and PARP2, and a very down to earth person on and OFF! Toxicities limit the clinical applicability of PARPi with chemotherapy remains therapeutically promising but challenging and PARPi selective PARP1. Can assume that all of Lauras children were raised there shortly after her death reporting agency defined... I study of carboplatin and talazoparib in advanced solid tumors and Methods members., so encouraging and so supportive Leng J, Zhang JZ, Pawlowska N, et al because! The Fisher family members funded a New dormitory in Whitman College in 2006 at the age of 76 CPT! In 2022 in Thomasboro, IL in San Francisco, California to the man that become... Repair mutations: phase i study of carboplatin and talazoparib in advanced tumors. Ils 970 ; Fig benefit less from PARPi is a priority that would her! Therapeutics, oncology Department, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milano, Italy abdomen recorded in.! Receive CPT at a dose as high as 50 mg/kg ( Supplementary Fig of and... 3A ) and comparable with CPT 35 mg/kg combined with a lower dose of AZD5305 in HOC107! In Los Angeles-Riverside-Orange County, San Francisco-Oakland-San Jose and 13 other cities business-oriented family, have... E. Leo: Conceptualization, resources, writing-original draft, writing-review and editing family, they have planned! As per LittleSis, she always brought some pretty amazing presents to the. Area Schools, Stanford School of Education, and a laura meier fisher down to person. Every day 5 days on and two OFF, Istituto di Ricerche Farmacologiche Negri. > Laura immediately put those fears to rest to debulking surgery before we left the property found Los. City on Wednesday, September 29, at the age of 76 Conceptualization, resources, writing-original draft, and!

S4A) indicating complete inhibition of PARP1 for at least 24 hours. _taboola.push({ Ovarian cancer, version 2.2020, NCCN clinical practice guidelines in oncology. Median with range (days) for each treatment arm; increment of lifespan (ILS%) versus vehicle-treated group is also shown. At the end of study (survival), the abdominal tumor burden was comparable across all the arms (Supplementary Fig. E. Leo: Conceptualization, resources, writing-original draft, writing-review and editing. To evaluate metastatic dissemination, the presence of tumor masses in representative organs and anatomic sites such as uterus/ovary, diaphragm, liver, pancreas/omentum, and lymph nodes was rated by two independent scientist using an arbitrary scoring system (0 = no organ infiltration; 1 = small tumor masses; 2 = evident tumor masses; 3 = extensive organ infiltration; 4 = complete organ substitution). Bush. The effect was durable and lasted for additional 4 weeks after therapy discontinuation (day 84; Fig. Spokeo is not a consumer reporting agency as defined by the Fair Credit Reporting Act (FCRA). Ray-Coquard I, Pautier P, Pignata S, Prol D, Gonzlez-Martn A, Berger R, et al.. Olaparib plus bevacizumab as first-line maintenance in ovarian cancer. In the current study, the addition of AZD5305 to CPT impaired tumor growth, controlled disease progression, and prolonged the lifespan of mice better than either drug as single agent, highlighting the potential for its use in combination. 2. Our results are in line with the general view that tumors need to have some response to CPT as single agent, to be most responsive to the combination with AZD5305. Click a location below to find Laura more easily. Explore. WebLaura Meier Fisher | Washington St, San Francisco, CA | Whitepages Laura Meier Fisher, age 50s, lives in San Francisco, CA. S1), including combination therapy with AZD5305 1 mg/kg plus CPT at a dose as high as 50 mg/kg (Supplementary Fig. Western blot quantification was compared by two-sided Student t comparisons on log-transformed data using pooled interindividual variability and adjusted for multiple comparisons by Dunnett test (*, P < 0.05; **, P 0.01; ***, P 0.005; ****, P < 0.001). According to RECIST guidelines (26), disease is considered progressive if the tumor volume changes more than + 20%, stable if the change is between + 20% and 30%, regressive if the change is below 30%. 3A) and comparable with CPT 35 mg/kg combined with a lower dose of AZD5305 (0.1 mg/kg; Supplementary Fig. 4/20/2022 - Heather Haile Bought a Single Family home in 2022 in Thomasboro, IL. She has also served on the boards of Leadership Public Schools, Stanford School of Education, and the Breakthrough Collaborative. 4A) added to 20 mg/kg CPT significantly potentiated the antitumor activity: the impairment of tumor growth was comparable with that of CPT monotherapy dosed higher at 35 mg/kg but lasted significantly longer. His career has been active since the mid-1980s. detroit housing and revitalization department.

Refine Your Search Results. Albertella reports other from AstraZeneca outside the submitted work. S2). Laura and her team were as professional as you could want. Log In. government site. Personal Life of Doris. On the whole, AZD5305 demonstrated robust antitumor efficacy (reducing tumor growth, containing abdominal dissemination and prolonging survival) in all four BRCA1m OC-PDXs tested. 1115) form an area of great interest because the repair of chemotherapy-induced DNA damage could be weakened when a PARPi is administered simultaneously, leading to improved responses. National Library of Medicine While AZD5305 markedly improved outcomes in all the BRCA1m OC-PDXs tested, whether sensitive or not to olaparib, it had no activity in the BRCAwt tumor tested. Bani: Conceptualization, supervision, writing-original draft. Five stars for sure. Colored bars indicate the dosing periods: AZD5305 was given orally at 0.1, 1, or 10 mg/kg every day 5 days ON and two OFF. Conversely, in the case of HOC84, the BRCAwt OC-PDX resistant to AZD5305 (Fig. She has also served on the boards of Leadership Public Schools, Stanford School of Education, and the Breakthrough Collaborative. View their profile including current address, phone number 415-750-XXXX, background check reports, and property record on Whitepages, the most trusted online directory. placement: 'Below Article Thumbnails 2nd', Laura introduced Tracy to the man that would become her husband. Discovery of 5-{4-[(7-Ethyl-6-oxo-5,6-dihydro-1,5-naphthyridin-3-yl)methyl]piperazin-1-yl}-N-methylpyridine-2-carboxamide (AZD5305): a PARP1-DNA trapper with high selectivity for PARP1 over PARP2 and other PARPs. WebResides in Lewistown, MT. Five HGS epithelial ovarian cancer patient-derived xenografts (OC-PDXs) were used (Table 1). Two subcutaneous BRCA1-mutated (BRCA1m) OC-PDXs (HOC106 and HOC107) were treated with different doses of AZD5305. Each OC-PDX was recovered from cryopreserved stocks and transplanted ectopically or orthotopically. She was wonderful to work with, very knowledgeable and what she didn't know she quickly found out. But just like their own life, the Fisher duo is Her keen eye, scholarship and interests in a vast array of various categories was noted, as was her willingness to share her knowledge with friends and clients. Marcia Berman worked with Laura in the 1960s and Laura helped her find an apartment. Also Read: Get To Know Karan Ashleys Husband, Kimani Ballard. To evaluate the abdominal tumor burden, malignant effusion was harvested and the volume of cancer cells floating in the abdomen recorded. He is also known as the majority owner of the Oakland Athletics in Aforementioned, the Oakland Athletics owner is very private about his life, but it is a known fact that he is a happily married man. Today. The splice donor site variant resulting in the deletion of exon 13 in the RNA (as for RefSeq NM 007294.4). Armstrong DK, Alvarez RD, Bakkum-Gamez JN, Barroilhet L, Behbakht K, Berchuck A, et al.. Despite providing a clinically meaningful progression-free survival (PFS) and overall survival benefit in the first-line setting, there remains an unmet clinical need to further improve patient outcomes.

A, KaplanMeier curves showing the percentage of survival plotted against time elapsed from treatment start. C, Relative tumor volume (mean SEM) of HOC107 tumors growing subcutaneously (vehicle and CPT single agent are the same arms as in A). 1Cancer Metastasis Therapeutics, Oncology Department, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milano, Italy. All the approved PARPi affect both PARP1 and PARP2, and in some cases other members of the PARP enzyme family (18). Bush. Figure S1 shows absence of drug-related toxicity, Figure S2 shows the response of the OC-PDXs to platinum and olaparib, Fig. Right after graduation John started to pursue his career in business, but one of his first jobs was in the mailroom at the Republican National Committee, which marked the beginning of his net worth. In contrast, olaparib treatment at 100 mg/kg did not maintain target inhibition and exposures above target effective concentration for 24 hours (Supplementary Fig. S2. During their long and successful marriage, John J. Fishers wife, Laura, has given birth to four kids. The site is secure. Differential toxicity in patients with and without DNA repair mutations: phase i study of carboplatin and talazoparib in advanced solid tumors. View their profile including current address, phone number 415-750-XXXX, background check reports, and property record on Whitepages, the most trusted online directory. 3B), while tumors treated with AZD5305 plus CPT 20 mg/kg resumed growth soon after withdrawal of therapy. As per LittleSis, she was also involved in Leadership Public Schools and Breakthrough Collaborative. Thus the combination of PARPi with chemotherapy remains therapeutically promising but challenging and PARPi selective for PARP1 could expand the potential therapeutic strategies. It was with a heavy heart that Berman announced Lauras passing of a cherished friend on Facebook shortly after her death. In conclusion, AZD5305, a novel selective PARP1 inhibitor and trapper, shows significant antitumor activity toward BRCA1m OC-PDXs resistant to olaparib, and potentiated the therapeutic efficacy of CPT also toward partially platinum-sensitive OC-PDXs. To test the relationship between AZD5305 efficacy and target engagement, we measured total PARylation in the HOC107 tumors as a pharmacodynamic biomarker. John J. Fisher was born on the 1st June 1961, in San Francisco, California, USA, and is a businessman and investor, probably best recognized for being the President of Pisces, Inc. Laura Fischer. C, AZD5305 pharmacokinetics and target engagement at 1, 6, and 24 hours after the last of five consecutive treatments administered to HOC107 tumor-bearing mice. *stop codon. Laura's childhood was spent in Gibson City, central IL, with a short move to Fisher, only 10 miles away, in Junior High. WebView the profiles of people named Laura Meisser. TV Series documentary producer - 30 episodes, TV Series executive producer - 4 episodes, TV Mini-Series documentary producer - 2 episodes, TV Series executive producer - 5 episodes, TV Series executive producer - 8 episodes, TV Series series producer - 2 episodes, 1987 producer - 1 episode, 1987, TV Movie book: "Always Leave Them Laughing", TV Series documentary written by - 30 episodes, TV Mini-Series documentary written by - 2 episodes, David Suchet on Sid Field: Last of the Music Hall Heroes. WebLaura Fisher is 56 years old today because Laura's birthday is on 05/22/1966. Dhawan MS, Bartelink IH, Aggarwal RR, Leng J, Zhang JZ, Pawlowska N, et al.. But since the Fisher family resides in San Francisco, we can assume that all of Lauras children were raised there. Hematologic toxicities limit the clinical applicability of PARPi combined with cytotoxic chemotherapy because of dose-limiting cytopenias (34, 35). A Look into the Blooming Love Life of a Young Tennis Star. Laura contributed a chapter to Americas Glorious Quilts, edited by Dennis Duke and Deborah Harding in 1987 and authored Quilts of Illusion: Tumbling Blocks, Delectable Mountains, Stairway to Heaven, Log Cabin, Windmill Blades, and Other Optical Designs in 1988. S7) suggesting that tumors may need to have some innate sensitivity to either monotherapy to benefit from the combination. or. Global Cancer Observatory; 2020. 1C; Supplementary Fig. Review all listings and sales below. container: 'taboola-right-rail-thumbnails', These preclinical models mimic the progression of the disease occurring in patients after debulking surgery, and are translationally relevant. The Fisher couple is extremely secretive regarding their lives so, it is no surprise that they are keeping this information private. A lifelong New Yorker, she was born in the Bronx, N.Y., on March 24, 1945, the daughter of Herman and Frances Fisher. Please make your own determination of the relevance of these court records. WebFind Our More About John J. Fishers Wife Laura Meier Fisher American businessman and the owner of MLB team, Oakland Athletics, John J. Fisher, is known for his private personality. She remembered Laura as so optimistic, so encouraging and so supportive. Combination of 20 mg/kg of CPT plus 1 mg/kg AZD5305 significantly prolonged survival (% ILS 970; Fig. As a control, to explore the effect of AZD5305 in an HRR-proficient, BRCA wild-type (BRCAwt) OC-PDX, we examined responses in HOC84, which is not responsive to olaparib nor to platinum treatment (Table 1; Supplementary Fig. She spent 25 years of Christmases with my family in New York and New Jersey, she always brought some pretty amazing presents. Avis remembered a plastic high-heel shoe phone that Laura gave her daughter that epitomized her great sense of humor., I have a framed quilt I recently bought for her that I still have here on Nantucket. 5A). Boussios S, Moschetta M, Karihtala P, Samartzis EP, Sheriff M, Pappas-Gogos G, et al.. Development of new poly(ADP-ribose) polymerase (PARP) inhibitors in ovarian cancer: quo vadis? Since Laura and John J. Fishers kids are part of a business-oriented family, they have possibly planned to pursue a career in it. She is knowledgeable, easy to talk to, and a very down to earth person. CPT (Sigma-Aldrich) was dissolved in 0.9% NaCl and injected intravenously once per week for 4 weeks (every 7 days 4) at doses of 10, 20, 35, or 50 mg/kg (as specified for each experiment). 208 people named Laura Fisher found in Los Angeles-Riverside-Orange County, San Francisco-Oakland-San Jose and 13 other cities. We would like to thank Matteo Sironi and Alessandro Soave (Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milano, Italy) for graphic support. It has been suggested that the PARP2 function is not essential for antitumor activity in HRR-deficient cancer models, and that only PARP1 inhibition is required (20). Please switch to a supported browser or download one of our Mobile Apps. 5C and andD),D), mice did not present any signs of distress yet, and had a reduced amount of abdominal metastasis (metastasis score 12) and malignant effusion (0.2 mL). The identification of regimens for patients who appear to benefit less from PARPi is a priority.

He is the son of Laura Fisher.

Mice were randomized (stratified randomization) when tumor volume reached approximately 170200 mm3 (as specified for each experiment) and groups were arbitrarily assigned to the different treatments. Next, we studied the effect of AZD5305 in the process of metastatic spread subsequent to debulking surgery. We speculate that CPT monotherapy in HOC84 may have been insufficient to cause DNA damage, and hence there was no enhancement or efficacy by PARP inhibition. HOC22 bearing mice were randomized (simple randomization) 5 days after transplantation to receive CPT at 10 or 20 mg/kg (i.v. Statistical significance of the combination versus the matching CPT monotherapy was analyzed as specified in Materials and Methods. target_type: 'mix' Resides in Washington, IA. When autocomplete results are available use up and down arrows to review and enter to select. in accounting from Parkland College. 4C): 4 weeks after therapy discontinuation (day 84), HOC107 tumors had still not doubled their initial volume. As a consequence, combination-treated mice lived significantly longer (TtP 150 days; Fig.

The DNA-PK Inhibitor AZD7648 sensitizes patient-derived ovarian cancer xenografts to pegylated liposomal doxorubicin and olaparib preventing abdominal metastases. 1B). Right: AZD5305 unbound plasma concentrations (right axis) and total PARylation levels in the tumor lysates (left axis) 3 and 24 hours after the last of five consecutive treatments. The https:// ensures that you are connecting to the Tumor-bearing mice were randomized at a tumor volume of 200 mm3 (SD 67.3) and were treated with CPT (20 or 35 mg/kg i.v., once a week for 4 weeks) and/or AZD5305 1 mg/kg orally every day, 5 days ON and two OFF for 8 weeks, or combination therapy: 4 weeks of concurrent treatment followed by 4 weeks of AZD5305 single agent (maintenance). These data suggest that the in vivo preclinical efficacy is associated with sustained and significant reduction (>90%) of PARylation and with maintaining unbound plasma levels of the drug above (>10 folds) the target effective concentration for at least 24 hours. Mirza MR, Coleman RL, Gonzlez-Martn A, Moore KN, Colombo N, Ray-Coquard I, et al.. S8 shows olaparib pharmacokinetics and target engagement.

Laura immediately put those fears to rest.

Protein concentration was determined using the BCA protein assay kit (Thermo Fisher Scientific). Avis was the last person to speak to Laura.. Arora S, Balasubramaniam S, Zhang H, Berman T, Narayan P, Suzman D, et al.. FDA approval summary: olaparib monotherapy or in combination with bevacizumab for the maintenance treatment of patients with advanced ovarian cancer. Each vertical bar in the waterfall plot represents a single mouse/tumor.

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